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revealed a mechanism by which p53 increases FoxO3a ubiquitination levels through ubiquitin-conjugating enzyme E2 L6 (UBE2L6) and promotes aging in diabetic retinal endothelial cells, suggesting a novel therapeutic focus for the mitigation and treatment of DR (85)

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Biologische Wirkung [Bearbeiten | Quelltext bearbeiten] In experimentellen Studien wurden GHK-Cu verschiedene biologische Aktivitten zugeschrieben: Frderung der Wundheilung, unter anderem durch Stimulation von Fibroblasten [2] Beeinflussung der Kollagen- und Elastinsynthese [2] Modulation von Entzndungsprozessen Untersttzung der Angiogenese (Neubildung von Blutgefen) [3] Antioxidative Eigenschaften, unter anderem durch kupferabhngige Enzyme Zudem zeigen in-vitro-Untersuchungen, dass GHK-Cu die Genexpression zahlreicher Gene beeinflussen kann, die mit Gewebereparatur und Zellwachstum assoziiert sind

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